A new breakthrough therapy is stirring interest among lupus researchers, as CAR-T cell treatment may allow genetic adjustments to bolster immune response, offering the chance for patients to avoid lifelong medication.
According to a latest report by ITV has revealed the information.
With symptoms such as joint pain, skin disorders, fatigue, and organ inflammation, lupus patients usually need a long-term regimen of medications like ibuprofen, steroids, and immunosuppressants.
Lupus affects about 5 million people worldwide, most of whom are women.
In the UK, three patients with severe lupus entered remission with CAR-T cell therapy, and some no longer require medication. Professor Ben Parker of Manchester Royal Infirmary described this therapy as: “Ultimately, it offers a very radical treatment for lupus. “What currently is available are treatments that suppress the immune system, that you have to continually take, that are partially effective in most people, very effective in a few people and ineffective in a substantial number of patients with lupus.
“The CAR-T treatment offers something very different. In those people who’ve received it, they have been able to stop their immunosuppression after receiving CAR-T and remain in what’s called drug-free remission.”
Originally developed for cancer treatment, CAR-T cell therapy is now being explored as a potential treatment for lupus and other autoimmune conditions. This therapy involves altering the body’s cells genetically to help the immune system recognise and eliminate harmful cells.
In July of this year, Catherine received CAR-T cell therapy as the first UK patient at Manchester Royal Infirmary. Two other patients, including 50-year-old Katy Tinkler, who had lived with lupus for 30 years, were treated at University College Hospital. After her treatment this week, Katy shared her joy at being part of such an innovative trial.
Further information about the study can be found at this link.